爱是你我哪个电视剧歌母亲有抑郁症

爱是你我哪个电视剧歌母亲有抑郁症篇一
《母亲抑郁症导致多动症》

BMJ2014;349:g5315doi:10.1136/bmj.g5315(Published27August2014)

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RESEARCH

NEWS

nottoautism,saysstudy

AdrianO’Dowd

London

Womenwhotakeantidepressantswhilepregnantmayberaisingtheriskoftheirchilddevelopingattentiondeficithyperactivitydisorder(ADHD)butnotautism,astudypublishedinthejournalMolecularPsychiatryhasfound.1

TheUSresearchers,however,warnedthatanypotential

“modest”riskfromtakingantidepressantsshouldbeweighedagainstthepossibleconsequencesofnottreatingmaternaldepressionoranxietyineachindividualpatient.

Todiscontinueantidepressantsduringpregnancycouldincreasetheriskofrelapsefivefold,theysaid,andmaternaldepressionduringpregnancywasassociatedwithhealthcomplicationsforthemotherandchild.

Theauthorsconcluded,“Decisionmakingaboutantidepressantutilisationinpregnancyrequiresthattheseemergingrisks,aswellasbenefits,beweighedinthecontextoftheindividualpatientandfamily.”

RoyPerlis,leadauthorandapsychiatristatMassachusettsGeneralHospital,toldTheBMJ,“Ithinkourresults,takentogetherwithsomeotherstudiesthatdidnotfindsignificantrisk,shouldbereassuringtowomenwhoneedtotakeantidepressantmedicationsduringpregnancy.

Anapparentlyrapidincreaseinprevalenceofautismspectrumdisorder(ASD)overthepastdecadehasincreasedeffortstoidentifypotentiallymodifiablerisks,althoughexpertsbelievethatmuchoftheliabilityforautismisinheritedandthat

environmentalfactors,notyetclearlyidentified,mightaddtotherisk.

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Previousstudieshavehadcontradictoryfindingsaboutwhetherprenatalexposuretoserotonergicdrugsleadstoautism-likequalitiesinchildrenandwhetherinuteroexposuretoantidepressantsincreaseschildren’sautismliability.

AteamofresearchersfromthedepartmentofpsychiatryatMassachusettsGeneralHospitalinBoston,USA,thereforelookedintothesubjectinmoredepthtoseeifotherfactorsmightbeinvolved.Theystudiedassociationsbetweenprenatalantidepressantexposuresandtheneurodevelopmentaldisordersin1377childrenwithautism,2243withADHD,andamatchedgroupofchildrenwithoutthosedisorders,drawnfromthemedicalrecordsofalargehealthsystem.

“Iwouldalwaysadvisecautioninprescribingantidepressants;butweneedtokeepinmindthat,inmanycases,thebenefitsfaroutweightherisks.Acrucialpointisthatnotadequatelytreatingdepressionandanxietyinpregnancycanalsocarrysubstantialrisk.”

Theauthorsfoundthatantidepressantexposureduringpregnancywasassociatedwiththeriskofautism,buttheseverityofmaternalmentalillnessalsoseemedtoaffectthisrisk,andtheassociationwasnolongersignificantwhentheytookintoaccountthemother’shistoryofmajordepression.Conversely,therateofADHDwasslightlyincreasedinchildrenwhowereexposedtoantidepressantsprenatally,evenafteradjustingfortheseverityofmaternaldepression.

Overall,theresultsshowedthattheriskofautismpreviouslyobservedwithprenatalantidepressantexposuremightbebetterexplainedbytheriskassociatedwithmaternalillness.However,theyalsoshowedthatsuchexposurecouldbemodestlyassociatedwiththeriskofADHD.

Expertsreactedtothestudywithcaution.CelsoArango,

scientificdirectoroftheSpanishCentreforBiomedicalResearchinMentalHealthbasedinMadrid,said,“Fromthechild’sperspectiveitislikelythatthepotentialharmcausedbyanyincreasedriskofADHDorautismwouldbemuchlessthanthepotentialharmofhavingamother[with]depression.Thisresearchdoesnotmeanthatwomenshouldstoptakingtheirantidepressants.”

GuyGoodwin,presidentoftheEuropeanCollegeof

Neuropsychopharmacology,said,“Itremainspossible,evenlikely,thattheeffectobservedisduetoincreasedgeneticrisksofpsychiatricdisorderintheoffspringofthewomenprescribedantidepressants,ratherthantheeffectsofthe

drugs.”

TheauthorssaidthatcliniciansshouldbecarefulaboutchangingtheirprescribingpracticesoradviceuntilfurtherstudieshadbeencarriedouttogetamorepreciseestimateoftheeffectsofantidepressantsonADHDrisk.Theyadded,“Theconsequencesoffailingtotreatdepressioninpregnancywarrantemphasis.”

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ClementsCC,CastroVM,BlumenthalSR,RosenfieldHR,MurphySN,FavaM,etal.Prenatalantidepressantexposureisassociatedwithriskforattention-deficithyperactivitydisorderbutnotautismspectrumdisorderinalargehealthsystem.MolecularPsychiatry2014;publishedonline26August.doi:10.1038/MP.2014.90.

TorjesenI.DepressionandSSRIuseinpregnancyassociatedwithtraitsofautisminchildren.BMJ2014;349:g4835.

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BMJ2014;349:g5315doi:10.1136/bmj.g5315(Published27August2014)Page2of2

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RaiD,LeeBK,DalmanC,GoldingJ,LewisG,MagnussonC.Parentaldepression,maternalantidepressantuseduringpregnancy,andriskofautismspectrumdisorders:populationbasedcase-controlstudy.BMJ2013;346:f2059.

CroenLA,GretherJK,YoshidaCK,OdouliR,HendrickV.Antidepressantuseduringpregnancyandchildhoodautismspectrumdisorders.ArchGenPsychiatry2011;68:1104-12.

Citethisas:BMJ2014;349:g5315

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爱是你我哪个电视剧歌母亲有抑郁症篇二
《母亲抑郁症子女易患精神疾病病理机制的研究进展》